The ability of E7449 to inhibit the action of human recombinant PARP1, mouse recombinant PARP2 or human recombinant TNKS1 was firm utilizing chemiluminescent PARP or tankyrase assay kits from Trevigen, subsequent the maker's instructions. Intra-articular injection of Torin 1reduces degeneration of articular cartilage in collagenase-induced OA by autophagy activation. LUM/IVA https://fredericki544ewq6.wikikali.com/user