Prevent concomitant usage of tucatinib with CYP3A substrates, where by negligible concentration changes may possibly bring on major or life-threatening toxicities. If unavoidable, minimize CYP3A substrate dose according to item labeling. cortisone will decrease the extent or influence of midazolam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. There are https://johnt479acd4.wikipresses.com/user